Ayala Center, along EDSA and Ayala Avenue is the most known commercial center in the city. Developed by the Ayala Corporation, it contains two shopping malls, Glorietta and Greenbelt, five hotels, and an office building. The larger of the two shopping malls is Glorietta, which itself is a cluster of malls. Rising from Glorietta 4 is the Ascott Tower(formerly Oakwood Premier), a luxurious hotel-apartment residence at the heart of the center. Along the periphery of Glorietta are three department stores: SM Department Store Makati, Rustan's, and the Landmark. Across Makati Avenue from Glorietta is Greenbelt. This is one of the most sophisticated, modern, and expensive malls in the country. Greenbelt features dozens of coffee stores and restaurants, all overlooking a well-landscaped green park at the center where a domed Catholic chapel dominates the skyline. Other hotels in the vicinity of Ayala Center are the Makati Shangri-la Hotel, the Manila Peninsula, the Dusit Hotel Nikkō, Manila Garden, the Hotel Intercontinental Manila, and Renaissance Makati City Hotel.

Rockwell Center is the other first-class shopping center in Makati. Rockwell features the large Power Plant Mall popular with expatriates. At the periphery of the center are many high-class residential condominium towers, the Asian Eye Institute, and the Ateneo de Manila Professional Schools main campus, which houses the Ateneo Law School, the Ateneo Graduate School of Business, and the Ateneo School of Government.

Other shopping centers. The Cash and Carry Supermarket in the west along South Luzon Expressway (SLEX) features many products at low prices. Makati Cinema Square, along Pasong Tamo Road, used to be a popular shopping mall with the residents. Adjacent to the Makati Cinema Square is the big and modern Waltermart Mall. The Guadalupe Commercial Center, along EDSA and Pasig River is a middle-class shopping center frequented by residents from the poorer areas of Makati. PureGold is another independent Supermarket located at the end of J.P. Rizal Street, Barangay Singkamas. Shopwise, another popular Supermarket Chain in the Philippines, is situated at Pasong Tamo corner Vito Cruz